Second malignant neoplasms after treatment of childhood acute lymphoblastic leukemia.

  title={Second malignant neoplasms after treatment of childhood acute lymphoblastic leukemia.},
  author={Kjeld Schmiegelow and Mette Frandsen Levinsen and Andishe Attarbaschi and Andr{\'e} Baruchel and Meenakshi Devidas and Gabriele M Escherich and Brenda E. S. Gibson and Christiane Heydrich and Keizo Horibe and Yasushi Ishida and Der-Cherng Liang and Franco Locatelli and G{\'e}rard Michel and Rob Pieters and Caroline Piette and Ching-Hon Pui and Susana C. Raimondi and Lewis B. Silverman and Martin Stanulla and Batia Stark and Naomi Joan Winick and Maria Grazia Valsecchi},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={31 19},
PURPOSE Second malignant neoplasms (SMNs) after diagnosis of childhood acute lymphoblastic leukemia (ALL) are rare events. PATIENTS AND METHODS We analyzed data on risk factors and outcomes of 642 children with SMNs occurring after treatment for ALL from 18 collaborative study groups between 1980 and 2007. RESULTS Acute myeloid leukemia (AML; n = 186), myelodysplastic syndrome (MDS; n = 69), and nonmeningioma brain tumor (n = 116) were the most common types of SMNs and had the poorest… CONTINUE READING
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