Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III.

@article{Hadi2000SecondHP,
  title={Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III.},
  author={Masood Z. Hadi and David M Wilson},
  journal={Environmental and molecular mutagenesis},
  year={2000},
  volume={36 4},
  pages={312-24}
}
There are two major apurinic/apyrimidinic (AP) endonuclease/3'-diesterase families designated after the Escherichia coli proteins exonuclease III (ExoIII) and endonuclease IV (EndoIV). These repair proteins function to excise mutagenic and cytotoxic AP sites or 3'-phosphate/phosphoglycolate groups from DNA. In mammals, the predominant repair endonuclease is Ape1, a homolog of ExoIII, whereas a mammalian homolog to EndoIV has not been identified to date. We have identified a human protein termed… CONTINUE READING

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