Second hand smoke and COPD: lessons from animal studies

  title={Second hand smoke and COPD: lessons from animal studies},
  author={Monica Goldklang and Sarah M. Marks and Jeanine M D'armiento},
  booktitle={Front. Physiol.},
Exposure to second hand smoke is a major cause of chronic obstructive pulmonary disease (COPD) in the non-smoker. In this review we explore the use of animal smoke exposure models and their insight into disease pathogenesis. The methods of smoke exposure, including exposure delivery systems, are described. Key findings from the acute and chronic smoke exposure models are outlined, including descriptions of the inflammation processes, proteases involved, oxidative stress, and apoptosis. Finally… CONTINUE READING
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Frontiers in Physiology | Respiratory Physiology

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