Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis

@article{Leucht2009SecondgenerationVF,
  title={Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis},
  author={S. Leucht and C. Corves and D. Arbter and R. Engel and J. Davis},
  journal={The Lancet},
  year={2009},
  volume={373},
  pages={31-41}
}
  • S. Leucht, C. Corves, +2 authors J. Davis
  • Published 2009
  • Medicine
  • The Lancet
  • BACKGROUND Because of the debate about whether second-generation antipsychotic drugs are better than first-generation antipsychotic drugs, we did a meta-analysis of randomised controlled trials to compare the effects of these two types of drugs in patients with schizophrenia. [...] Key MethodFINDINGS We included 150 double-blind, mostly short-term, studies, with 21 533 participants. We excluded open studies because they systematically favoured second-generation drugs. Four of these drugs were better than…Expand Abstract

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The investigators hypothesis is that an antipsychotic drug combination of low-dose olanzapine plus low-dose trifluoperazine is similar to regular-dose olanzapine monotherapy in efficacy… Expand
    ConditionsSchizophrenia
    InterventionDrug
    Second-generation antipsychotics for schizophrenia: can we resolve the conflict?
    • 143
    • Open Access

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