Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis

@article{Leucht2009SecondgenerationVF,
  title={Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis},
  author={S. Leucht and C. Corves and D. Arbter and R. Engel and Chunbo Li and John M. Davis},
  journal={The Lancet},
  year={2009},
  volume={373},
  pages={31-41}
}
BACKGROUND Because of the debate about whether second-generation antipsychotic drugs are better than first-generation antipsychotic drugs, we did a meta-analysis of randomised controlled trials to compare the effects of these two types of drugs in patients with schizophrenia. [...] Key MethodFINDINGS We included 150 double-blind, mostly short-term, studies, with 21 533 participants. We excluded open studies because they systematically favoured second-generation drugs. Four of these drugs were better than…Expand

Paper Mentions

Interventional Clinical Trial
The investigators hypothesis is that an antipsychotic drug combination of low-dose olanzapine plus low-dose trifluoperazine is similar to regular-dose olanzapine monotherapy in efficacy… Expand
ConditionsSchizophrenia
InterventionDrug
Second-generation antipsychotics for schizophrenia: can we resolve the conflict?
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