Second generation of fucose-based DC-SIGN ligands: affinity improvement and specificity versus Langerin.

Abstract

DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity… (More)
DOI: 10.1039/c1ob05573a

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