Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice.

@article{Klingerman2014SecondgenerationAC,
  title={Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice.},
  author={C. M. Klingerman and Michelle E. Stipanovic and Mohammad I. Bader and C. Lynch},
  journal={Schizophrenia bulletin},
  year={2014},
  volume={40 2},
  pages={
          327-40
        }
}
  • C. M. Klingerman, Michelle E. Stipanovic, +1 author C. Lynch
  • Published 2014
  • Chemistry, Medicine
  • Schizophrenia bulletin
  • Some second-generation antipsychotics (SGAs) increase insulin resistance and fat oxidation, but counter intuitively they do not activate lipolysis. This seems unsustainable for meeting energy demands. Here, we measured dose-dependent effects of SGAs on rates of oxygen consumption (VO2), respiratory exchange ratio (RER), and physical activity in C57BL/6J mice. The role of H1-histamine receptors and consequences of blocking fat oxidation were also examined. Olanzapine, risperidone, and clozapine… CONTINUE READING
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