Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine

  title={Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine},
  author={M. Owens and D. Knight and C. Nemeroff},
  journal={Biological Psychiatry},
  • M. Owens, D. Knight, C. Nemeroff
  • Published 2001
  • Chemistry, Medicine
  • Biological Psychiatry
  • BACKGROUND Single isomers of the selective serotonin reuptake inhibitors citalopram (escitalopram, S-citalopram) and fluoxetine (R-fluoxetine) are currently under development for the treatment of depression and other psychiatric disorders. Previous studies conducted in laboratory animals have revealed that the biological effects on serotonin reuptake for citalopram reside in the S enantiomer. In contrast, both enantiomers of fluoxetine contribute to its biological activity. METHODS In the… CONTINUE READING
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