Second generation 4-(4-methyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile PKCtheta inhibitors.

Abstract

Thieno[2,3-b]pyridine-5-carbonitrile 16 with a 4-methyl-5-indolylamine at C-4 and a 5-methoxy-2-(dimethylamino)-methylphenyl group at C-2 had an IC(50) value of 16 nM for the inhibition of PKCtheta. While moderate inhibition of PKCdelta was also observed (IC(50)=130 nM), 16 had IC(50) values of greater than 5 microM against Lyn and other members of the Src… (More)
DOI: 10.1016/j.bmcl.2008.12.021

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Cite this paper

@article{Wu2009SecondG4, title={Second generation 4-(4-methyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile PKCtheta inhibitors.}, author={Biqi Wu and Diane H Boschelli and Julie M. Lee and Xiaoke Yang and Divya Chaudhary}, journal={Bioorganic & medicinal chemistry letters}, year={2009}, volume={19 3}, pages={766-9} }