Second esophageal tumors in patients with head and neck squamous cell carcinoma: an assessment of clonal relationships.

@article{Califano1999SecondET,
  title={Second esophageal tumors in patients with head and neck squamous cell carcinoma: an assessment of clonal relationships.},
  author={Joseph A. Califano and P L Stanley Leong and Wayne M Koch and Claus Ferdinand Eisenberger and David Sidransky and William H Westra},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1999},
  volume={5 7},
  pages={1862-7}
}
Patients with squamous cell carcinoma of the head and neck (HNSCC) often develop second carcinomas elsewhere in the upper aerodigestive tract. Some of these paired tumors share a common origin, reflecting the ability of a single progenitor cell to replicate, expand, and populate contiguous regions of the upper aerodigestive tract-a process referred to as clonal expansion. The geographical limitations of clonal expansion, however, have not been adequately addressed. For example, it is not known… CONTINUE READING

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