Second- and Third-Generation Beta-Blocking Drugs in Chronic Heart Failure

@article{Bristow1997SecondAT,
  title={Second- and Third-Generation Beta-Blocking Drugs in Chronic Heart Failure},
  author={Michael R. Bristow and William T. Abraham and Tsutomu Yoshikawa and Michel White and Brack G. Hattler and Thomas S. Crisman and Brian D. Lowes and Alastair D. Robertson and Patti Larrabee and Edward M. Gilbert},
  journal={Cardiovascular Drugs and Therapy},
  year={1997},
  volume={11},
  pages={291-296}
}
The left-ventricular (LV) functional, hemodynamic, and antiadrenergic effects of metoprolol, bucindolol, and carvedilol have been compared in three concurrent placebo-controlled clinical trials in patients with symptomatic idiopathic dilated cardiomyopathy. All three drugs were well tolerated, all produced at least moderate degrees of β-blockade as assessed… CONTINUE READING