Second Primary Tumors in Patients with Head and Neck Cancer

@article{Priante2011SecondPT,
  title={Second Primary Tumors in Patients with Head and Neck Cancer},
  author={Antonio Vitor Martins Priante and Emanuel Celice Castilho and Luiz Paulo Kowalski},
  journal={Current Oncology Reports},
  year={2011},
  volume={13},
  pages={132-137}
}
This is a review on second primary tumors in patients with head and neck cancer. These patients have a high risk of developing other cancers simultaneously or subsequently. The incidence of multiple primary tumors in this population can be as high as 27%. Recurrences are the most common cause of treatment failure within the first 2 years of follow-up. After the third year the diagnosis of a second primary tumor becomes the most important cause of morbimortality in head and neck cancer patients… 
Second Primary Tumors in head and neck cancer patients: the importance of a "tailored" surveillance.
TLDR
Head and neck cancer survivors developing a second primary tumor have dismal prognosis andtailored surveillance is recommended.
Second primary cancers in head and neck cancer patients: a challenging entity.
TLDR
The current recommendations for follow-up in HNSCC patients treated with curative intent aim to evaluate treatment response, detect potentially late recurrences and assess long-term exposure to tobacco-derived and alcohol-derived carcinogens.
Multiple cancers of the head and neck.
TLDR
In the literature and in practice, a rare combination of multiple cancers is met, associations that appear to be "random", cannot be explained by any of the hypotheses developed: exposure to carcinogens, genetic susceptibility, and immunodeficiency or cancer treatments after index tumor.
Second primary tumours in head and neck cancer.
TLDR
The incidence of second primary tumours increased in the last decade, having a negative effect on survival, and alcohol and tobacco avoidance along with scheduled follow-up are suggested procedures to reduce its incidence.
Mutation Analysis of Second Primary Tumors in the Head and Neck Cancer by Next Generation Sequencing
TLDR
This mutant verification only in second primary tumors might be the cause of the second primary oral cancer in head and neck cancer patients.
Multiple Primary Malignancies in Head and Neck Cancer: A University Hospital Experience Over a Five-Year Period
TLDR
Findings from this study highlight the importance of long-term follow-up of HNT patients for early detection of SPMs, increasing the chance of providing treatment with curative intent and improving patient outcomes and survival.
Incidence of second primary malignancies in patients with treated head and neck cancer: a comprehensive review of literature
Abstract Background: Increased incidence of a second primary aero-digestive malignancy after an index head and neck cancer (HNC) is well-documented. Furthermore, a clear set of surveillance
Screening for synchronous esophageal second primary tumors in patients with head and neck cancer
TLDR
It is recommended that screening for synchronous ESPTs should be considered in a selected group of patients with HNSCC, as there is an increased risk of developing esophageal second primary tumors (ESPTs) in this population.
Risk of second primary malignancy in patients with sinonasal tumors: a population‐based cohort study
TLDR
This study assesses overall and site‐specific risks of SPM following treatment of sinonasal malignancy and suggests that frequent development of second primary malignancies is a cause for concern.
Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization
TLDR
The objective of this study was to report the case of a patient who developed six oral cavity tumors in five years of treatment and demonstrate the immunohistochemical changes for p53 and Ki-67, routinely used to assess dysplasic regions.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 72 REFERENCES
Second primary malignancies in patients with cancer of the head and neck.
TLDR
The SPMs are a growing problem with better survival after treatment of the first malignancy with special attention to the development of SPM in patients with cancer of the head and neck.
Multiple primary cancer in patients with cancer of the head and neck: second cancer of the head and neck, esophagus, and lung.
TLDR
The clinician must diagnose and treat second cancers to extend the survival of patients with a good prognosis for control of the initial head and neck cancer.
Second malignant neoplasms in patients successfully treated with multimodality treatment for advanced head and neck cancer.
TLDR
Future efforts at improving the survival of patients with advanced head and neck cancer must include strategies aimed at decreasing the incidence and the morbidity and mortality from second malignant neoplasms.
Meta-Analysis of Second Malignant Tumors in Head and Neck Cancer: The Case for an Endoscopic Screening Protocol
TLDR
Routine interval endoscopic intervention within 2 years of treatment is recommended for optimum detection of second primaries in head and neck cancer patients and a lifetime of clinical surveillance is suggested for aerodigestive tract second neoplasms in oral cavity, oropharynx, and hypopharynx cancer patients.
Survival in second primary malignancies of patients with head and neck cancer
TLDR
Since more than 40 per cent of the metachronous second primaries in patients with a history of head and neck malignancy occur beyond the five-year follow-up period, an extended protocol with individually adjusted close monitoring of high-risk patients seems appropriate.
Second Primary Malignancies in the Head and Neck Cancer Patient
TLDR
The literature is reviewed and current research is presented regarding the history, epidemiology, etiology, diagnosis, and treatment of second primary malignancies.
Second primary malignancies in head and neck cancer patients
TLDR
The examinations revealed a high prevalence of curable stage SPM in HNSCC patients, and Adapting a surveillance scheme including a chest CT is recommended.
Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck.
TLDR
Daily treatment with high doses of isotretinoin is effective in preventing second primary tumors in patients who have been treated for squamous-cell carcinoma of the head and neck, although it does not prevent recurrences of the original tumor.
Overexpression of p53 in tumor-distant epithelia of head and neck cancer patients is associated with an increased incidence of second primary carcinoma.
  • N. Homann, M. Nees, +4 authors F. Bosch
  • Medicine, Biology
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2001
TLDR
IHC staining for p53 overexpression in tumor-distant epithelia provides a simple and rapid tool to identify head and neck cancer patients at increased risk of developing second primary tumors.
Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries
TLDR
Excess second head and neck cancer risk was observed 10 years after diagnosis with lymphohaematopoietic cancers, and patterns were consistent with the notion that the pattern of cancer in survivors of head andneck cancer is dominated by the effect of tobacco smoking and alcohol drinking.
...
1
2
3
4
5
...