Second Harmonic Generation Guided Raman Spectroscopy for Sensitive Detection of Polymorph Transitions.

@article{Chowdhury2017SecondHG,
  title={Second Harmonic Generation Guided Raman Spectroscopy for Sensitive Detection of Polymorph Transitions.},
  author={Azhad U Chowdhury and Dong Hye Ye and Zhengtian Song and Shijie Zhang and Hartmut G. Hedderich and Babita Mallick and Satyanarayana Thirunahari and Srividya Ramakrishnan and Atanu Sengupta and Ellen J. Gualtieri and Charles A. Bouman and Garth J. Simpson},
  journal={Analytical chemistry},
  year={2017},
  volume={89 11},
  pages={5958-5965}
}
Second harmonic generation (SHG) was integrated with Raman spectroscopy for the analysis of pharmaceutical materials. Particulate formulations of clopidogrel bisulfate were prepared in two crystal forms (Form I and Form II). Image analysis approaches enable automated identification of particles by bright field imaging, followed by classification by SHG… CONTINUE READING