Second-Generation Synthesis of (+)-Fastigiatine Inspired by Conformational Studies.

  title={Second-Generation Synthesis of (+)-Fastigiatine Inspired by Conformational Studies.},
  author={Jacob C DeForest and Renzo A. Samame and Gregory M Suryn and Alexander Burtea and Scott D Rychnovsky},
  journal={The Journal of organic chemistry},
(+)-Fastigiatine is a complex alkaloid isolated from the alpine club moss Lycopodium fastigatum, most commonly found in New Zealand. It has been the subject of two successful synthetic campaigns. A second-generation route toward fastigiatine was developed to resolve two problematic steps from our initial synthesis. Selective reduction and protection of the… CONTINUE READING