Secalonic acid D reduced the percentage of side populations by down-regulating the expression of ABCG2.

@article{Hu2013SecalonicAD,
  title={Secalonic acid D reduced the percentage of side populations by down-regulating the expression of ABCG2.},
  author={Ya-peng Hu and Li-yang Tao and Fang Wang and Jian-Ye Zhang and Yong-ju Liang and Liwu Fu},
  journal={Biochemical pharmacology},
  year={2013},
  volume={85 11},
  pages={1619-25}
}
The side population cells characterized by the ability to transport Hoechst 33342 out of cells have been identified as cancer stem-like cells. ABCG2 is found to confer the side population (SP) phenotype, multidrug resistance (MDR) and tumor recurrence. In this study, we found secalonic acid D (SAD), a metabolite of marine-derived mangrove endophytic fungus, showed potent anticancer effect on ABCB1-, ABCC1- and ABCG2- overexpressing multidrug resistance cells by MTT assay. Furthermore, SAD could… CONTINUE READING
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Cancer stem cell niche: the place to be

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