Secalonic acid D-induced changes in palatal cyclic AMP and cyclic GMP in developing mice.

@article{Eldeib1988SecalonicAD,
  title={Secalonic acid D-induced changes in palatal cyclic AMP and cyclic GMP in developing mice.},
  author={M M Eldeib and C. S. Shiva Shankar Reddy},
  journal={Teratology},
  year={1988},
  volume={37 4},
  pages={343-52}
}
Secalonic acid D (SAD) induces cleft palate in the developing mouse by an unknown mechanism. To investigate possible roles of cyclic nucleotides (cAMP and cGMP) in the teratogenesis of SAD, cAMP and cGMP levels were measured in the extracts of fetal palates of gestational age 13(0) through 16(12) (days(hours]. Fetuses were obtained from pregnant CD-1 mice treated on day 11(0) of gestation, with either 5% (wt./vol.) sodium bicarbonate (NaHCO3, control) or 30 mg/kg of SAD in 5% NaHCO3… CONTINUE READING