SecY and integral membrane components of the Escherichia coli protein translocation system.

@article{Ito1992SecYAI,
  title={SecY and integral membrane components of the Escherichia coli protein translocation system.},
  author={Koreaki Ito},
  journal={Molecular microbiology},
  year={1992},
  volume={6 17},
  pages={2423-8}
}
Genetic approaches can address the question of how integral membrane Sec factors interact with each other and facilitate protein translocation across the cytoplasmic membrane of E. coli. This review summarizes genetic analyses of SecY, SecE and some other protein translocation factors, utilizing 'prl' mutations, 'sec' mutations, 'suppressor-directed inactivation', 'Sec titration', dominant negative mutations and their suppressors. Evidence suggests that co-ordinate participation of SecY, SecE… CONTINUE READING

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