SecDF of Bacillus subtilis, a molecular Siamese twin required for the efficient secretion of proteins.

@article{Bolhuis1998SecDFOB,
  title={SecDF of Bacillus subtilis, a molecular Siamese twin required for the efficient secretion of proteins.},
  author={Albert Bolhuis and C. P. Broekhuizen and Alexander Sorokin and Maarten L. van Roosmalen and Garard Venema and Sierd Bron and Wim J Quax and Jan Maarten van Dijl},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 33},
  pages={21217-24}
}
In the present studies, we show that the SecD and SecF equivalents of the Gram-positive bacterium Bacillus subtilis are jointly present in one polypeptide, denoted SecDF, that is required to maintain a high capacity for protein secretion. Unlike the SecD subunit of the pre-protein translocase of Escherichia coli, SecDF of B. subtilis was not required for the release of a mature secretory protein from the membrane, indicating that SecDF is involved in earlier translocation steps. Strains lacking… CONTINUE READING

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