SecD and SecF facilitate protein export in Escherichia coli.

@article{Pogliano1994SecDAS,
  title={SecD and SecF facilitate protein export in Escherichia coli.},
  author={Joseph A. Pogliano and Jon et Beckwith},
  journal={The EMBO journal},
  year={1994},
  volume={13 3},
  pages={554-61}
}
We show here that the rate of protein translocation in the bacterium Escherichia coli depends on the levels of the SecD and SecF proteins in the cell. Overexpression of SecD and SecF stimulates translocation in wild type cells and improves export of proteins with mutant signal sequences. Depletion of SecD and SecF from the cell greatly reduces but does not abolish protein translocation. A secDF::kan null mutant deleted for the genes encoding both proteins is cold-sensitive for growth and… CONTINUE READING

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