SecA supports a constant rate of preprotein translocation.

@article{Tomkiewicz2006SecASA,
  title={SecA supports a constant rate of preprotein translocation.},
  author={Danuta Tomkiewicz and Nico Nouwen and Ruud G H van Leeuwen and Sander Tans and Arnold J M Driessen},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 23},
  pages={15709-13}
}
In Escherichia coli, secretory proteins (preproteins) are translocated across the cytoplasmic membrane by the Sec system composed of a protein-conducting channel, SecYEG, and an ATP-dependent motor protein, SecA. After binding of the preprotein to SecYEG-bound SecA, cycles of ATP binding and hydrolysis by SecA are thought to drive the stepwise translocation of the preprotein across the membrane. To address how the length of a preprotein substrate affects the SecA-driven translocation process… CONTINUE READING
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