SecA drives transmembrane insertion of RodZ, an unusual single-span membrane protein.

@article{Rawat2015SecADT,
  title={SecA drives transmembrane insertion of RodZ, an unusual single-span membrane protein.},
  author={Swati Rawat and Lu Zhu and Eric Lindner and Ross E. Dalbey and Stephen H White},
  journal={Journal of molecular biology},
  year={2015},
  volume={427 5},
  pages={
          1023-37
        }
}
The transmembrane (TM) helices of most type II single-span membrane proteins (S-SMPs) of Escherichia coli occur near the N-terminus, where the cell's targeting mechanisms can readily identify it as it emerges from the ribosome. However, the TM helices of a few S-SMPs, such as RodZ, occur a hundred or more residues downstream from the N-terminus, which raises fundamental questions about targeting and assembly. Because of RodZ's novelty and potential usefulness for understanding TM helix… CONTINUE READING
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