Sec62 promotes early recurrence of hepatocellular carcinoma through activating integrinα/CAV1 signalling

@article{Du2019Sec62PE,
  title={Sec62 promotes early recurrence of hepatocellular carcinoma through activating integrin$\alpha$/CAV1 signalling},
  author={Juan Du and Zhi-hao Zhao and Hetong Zhao and Dong Liu and Hongcan Liu and Josephine Chen and Binbin Cheng and Xiao-feng Zhai and Zi-fei Yin and Ya'ni Zhang and Changquan Ling},
  journal={Oncogenesis},
  year={2019},
  volume={8}
}
Postsurgical recurrence within 2 years is the major cause of poor survival of hepatocellular carcinoma (HCC) patients. However, the molecular mechanism underlying HCC recurrence remains unclear. Here, we distinguish the function and mechanism of Sec62 in promoting HCC recurrence. The correlation between Sec62 and early recurrence was demonstrated in 60 HCC samples from a prospective study. HCC cells with Sec62 knockdown (Sec62KD) or overexpression (Sec62OE) were used to determine the potential… Expand
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