Sec61p is the main ribosome receptor in the endoplasmic reticulum of Saccharomyces cerevisiae.

Abstract

A characteristic feature of the co-translational protein translocation into the endoplasmic reticulum (ER) is the tight association of the translating ribosomes with the translocation sites in the membrane. Biochemical analyses identified the Sec61 complex as the main ribosome receptor in the ER of mammalian cells. Similar experiments using purified… (More)

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