Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p.

@article{Walter2001Sec61pindependentDO,
  title={Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p.},
  author={J{\"o}rn Walter and Jill Urban and Corinna Volkwein and Thomas M. Sommer},
  journal={The EMBO journal},
  year={2001},
  volume={20 12},
  pages={
          3124-31
        }
}
Tail-anchored proteins are distinct from other membrane proteins as they are thought to insert into the endoplasmic reticulum (ER) membrane independently of Sec61p translocation pores. These pores not only mediate import but are also assumed to catalyze export of proteins in a process called ER-associated protein degradation (ERAD). In order to examine the Sec61p dependence of the export of tail-anchored proteins, we analyzed the degradation pathway of a tail-anchored ER membrane protein, the… CONTINUE READING
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