Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1.


p27 has essential roles in cellular proliferation and migration, and reduced or cytoplasmic p27 is associated with poor clinical outcomes in a variety of human tumours. Jun activation domain-binding protein (Jab1)/constitutive photomorphogenic-9 signalosome 5 (CSN5) directly interacts with p27 promoting its translocation and cytoplasmic degradation. Sec6 is… (More)
DOI: 10.1016/j.cellsig.2014.06.003


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