Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling

@article{Aravind1999Sec14plikeDI,
  title={Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling},
  author={L. Aravind and Andrew F. Neuwald and Chris P. Ponting},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={R195-R197}
}
The small GTPases Ras and Rho, which perform central roles in eukaryotic signal transduction, cycle between active GTP-bound and inactive GDP-bound forms via interactions with GTPase-activating proteins (GAPs) and with guanine nucleotide exchange factors (GEFs) [1]. As a result, mutations in GAPs or GEFs are often associated with malignant transformation and have been the subject of intensive investigation. GAPs and GEFs typically possess multiple domains, some of which bind to membranes or… CONTINUE READING