Sec12p requires Rer1p for sorting to coatomer (COPI)-coated vesicles and retrieval to the ER.

@article{Bhm1997Sec12pRR,
  title={Sec12p requires Rer1p for sorting to coatomer (COPI)-coated vesicles and retrieval to the ER.},
  author={Jochen B{\"o}hm and François Letourneur and W Ballensiefen and Dmitri Ossipov and Corinne D{\'e}molli{\`e}re and Hans Dieter Schmitt},
  journal={Journal of cell science},
  year={1997},
  volume={110 ( Pt 8)},
  pages={991-1003}
}
In Saccharomyces cerevisiae cells lacking the Rer1 protein (Rer1p), the type II transmembrane protein Sec12p fails to be retained in the ER. The transmembrane domain of Sec12p is sufficient to confer Rer1p-dependent ER retention to other membrane proteins. In rer1 mutants a large part of the Sec12-derived proteins can escape to the late Golgi. In contrast, rer3 mutants accumulate Sec12-derived hybrid proteins carrying early Golgi modifications. We found that rer3 mutants harbour unique alleles… CONTINUE READING

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Kex2dependent invertase secretion as a tool to study the targeting of transmembrane proteins which are involved in ER→Golgi transport in yeast

  • J. Boehm, H. D. Ulrich, R. Ossig, H. D. Schmitt
  • EMBO J
  • 1994
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