Sec-dependent preprotein translocation in bacteria

  title={Sec-dependent preprotein translocation in bacteria},
  author={Tanneke den Blaauwen and Arnold J M Driessen},
  journal={Archives of Microbiology},
Translocation of precursor proteins across the cytoplasmic membrane in bacteria is mediated by a multi-subunit protein complex termed translocase, which consists of the integral membrane heterotrimer SecYEG and the peripheral homodimeric ATPase SecA. Preproteins are bound by the cytosolic molecular chaperone SecB and targeted in a complex with SecA to the translocation site at the cytoplasmic membrane. This interaction with SecYEG allows the SecA/preprotein complex to insert into the membrane… CONTINUE READING


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