Sebacoyl Dinalbuphine Ester Extended-release Injection for Long-acting Analgesia: A Multicenter, Randomized, Double-Blind, And Placebo-controlled Study in Hemorrhoidectomy Patients

  title={Sebacoyl Dinalbuphine Ester Extended-release Injection for Long-acting Analgesia: A Multicenter, Randomized, Double-Blind, And Placebo-controlled Study in Hemorrhoidectomy Patients},
  author={Chien-Yuh Yeh and Shu-Wen Jao and Jinn Shiun Chen and Chung-wei Fan and Hong-Hwa Chen and Paoshiu Hsieh and Chang-Chieh Wu and Chia-Cheng Lee and Yi-Hung Kuo and Meng-Chiao Hsieh and Wen-Shih Huang and Yuan‐Chiang Chung and T Y Liou and Hsi-Hsiung Chiu and Wen-ko Tseng and Ko-Chao Lee and Jeng‐Yi Wang},
  journal={The Clinical Journal of Pain},
Objectives: This study was conducted to evaluate the safety and efficacy of single sebacoyl dinalbuphine ester (SDE) injection (150 mg/2 mL) when administered intramuscularly to patients who underwent hemorrhoidectomy for postoperative long-acting analgesia. Methods: A total of 221 patients scheduled for hemorrhoidectomy from 6 centers in Taiwan were randomly divided into SDE group and placebo group, and received the treatment, vehicle or SDE, 1 day before the surgery. Visual analogue scale… 
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    JPMA. The Journal of the Pakistan Medical Association
  • 2003
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