Sebaceous glands in acne patients express high levels of neutral endopeptidase

  title={Sebaceous glands in acne patients express high levels of neutral endopeptidase},
  author={Masahiko Toyoda and M. Nakamura and Teruhiko Makino and Masayori Kagoura and Masaaki Morohashi},
  journal={Experimental Dermatology},
Abstract: Acne is a complex, chronic and common skin disorder of pilosebaceous units. Although it is known that exacerbation of acne results from emotional stress, the nature of the association between stress and acne remains unclear. This is due in part to the lack of substantial evidence regarding the participation of cutaneous neurogenic factors in the pathogenesis of acne. To examine the possible involvement of neurogenic factors in the etiology of acne, we used immunohistochemistry to… 
New Aspects in Acne Inflammation
Findings suggest that SP may stimulate lipogenesis of the sebaceous glands which may be followed by proliferation of Propionibacterium acnes, and may yield a potent influence on the seBaceous glands by provocation of inflammatory reactions via mast cells.
The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris
Immunohistochemistry data suggest that NP, such as the complete CRH system and MC-1R, are involved in the pathogenesis of acne.
Morphometry of pilosebaceous unit and immunohistochemical expression of substance P and neurokinin-1 receptor in acne vulgaris
SP and its receptor NK-1R seem to be important in the regulation of sebaceous gland function and provide a new insight into the involvement of the cutaneous nervous system in the pathogenesis of acne.
Beyond acne: Current aspects of sebaceous gland biology and function
How sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases is discussed.
The role of inflammation in the pathology of acne.
  • E. Tanghetti
  • Biology, Medicine
    The Journal of clinical and aesthetic dermatology
  • 2013
Evidence is presented to support the notion that acne is primarily an inflammatory disease, challenging the current nomenclature of noninflammatory versus inflammatory acne lesions and suggesting that the nomenClature is outdated and incorrect.
New developments in our understanding of acne pathogenesis and treatment
A summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years is provided.
Increased in situ expression of melanocortin‐1 receptor in sebaceous glands of lesional skin of patients with acne vulgaris
Investigation by immunohistochemistry suggests that melanocortin‐1 receptor is involved in the pathogenesis of acne, and Sebocytes and keratinocytes of the ductus seboglandularis of acne‐involved and non‐involved skin showed very intense melanoc Cortin‐ 1 receptor expression in contrast to less intense scattered immunoreactivity in normal skin samples.
Sebaceous gland in human skin--the fantastic future of a skin appendage.
  • C. Zouboulis
  • Biology
    The Journal of investigative dermatology
  • 2003
Th Thiboutot and colleagues have shown that all enzymes required for utilizing cholesterol as a substrate for steroidogenesis are present in human sebocytes with P450 side chain cleavage enzyme, adrenodoxin reductase, and P450c17.
Frontiers in sebaceous gland biology and pathology
Abstract:  The development of experimental models for the in vitro study of human sebaceous gland turned down the theory of a phylogenetic relict and led to the identification of several, unknown or
Endocrinology and immunology of acne: Two sides of the same coin
The major role of inflammation in acne development is confirmed based on published molecular data sets and new therapeutic efforts on anti‐inflammatory/immunologically active concepts, which are able to regulate sebaceous lipogenesis.


The Pilosebaceous Unit Is Part of the Skin Immune System
The successful cultivation of sebocytes will provide a model by which the effect of these mediators can be studied in detail in order to shed light onto the various pathophysiological conditions of seBaceous glands.
Neutral endopeptidase expression and distribution in human skin and wounds.
This is the first evidence that keratinocytes produce neutral endopeptidase, which may terminate the proinflammatory and mitogenic actions of neuropeptides in normal skin and wounds.
Endothelin and neutral endopeptidase in the endometrium of women with menorrhagia.
In menorrhagia, stromal endothelin immunoreactivity was not different from the normal cycle and although neutral endopeptidase immunostaining in stroma was similar to the secretory phase of normal endometrium, cyclical variation was absent.
Modulation of neurogenic inflammation by neutral endopeptidase.
It is suggested that decreased NEP activity will result in exaggerated neurogenic inflammation and may play an important role in inflammatory diseases in airways and drugs that cause up-regulation of NEP may play a therapeutic role by suppressing neurogenic responses.
Immunological localization of neuropeptide-degrading enzymes in the nasal mucosa.
Results show that NEP secretion is regulated by a glandular, cholinergic control and ACE and CPN secretion are regulated by vascular permeability.
Neuropeptides in skin from patients with atopic dermatitis: an immunohistochemical study
The distribution and localization of several neuropeptides were investigated in the lichenified lesions of 11 patients with atopic dermatitis using indirect immunofluorescence, suggesting a possible involvement of some neuropePTides in the pathomechanisms of atopy dermatitis.
Regulation of neurogenic inflammation by neutral endopeptidase.
  • J. Nadel
  • Biology
    The American review of respiratory disease
  • 1992
The enzyme neutral endopeptidase is bound to the membranes of selected cells in the airways that have receptors for tachykinins, and it modulates smooth muscle contraction, gland secretion, cough, vascular permeability, and neutrophil adhesion.
Substance P is diminished and vasoactive intestinal peptide is augmented in psoriatic lesions and these peptides exert disparate effects on the proliferation of cultured human keratinocytes.
The imbalance of cutaneous VIP and SP and their disparate effects on the proliferation of normal human keratinocytes in culture would suggest that these peptides are involved in the pathogenesis of psoriasis and may exert different modulatory activities in the mechanisms underlying the psoriatic lesion.
Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux.
NEP, therefore, is a signal transduction and possibly a growth modulator for both SCLC and NSCLC, emphasizing the role of neuropeptides in the pathogenesis of the major histological forms of lung cancer.
Neuropeptides and skin inflammation.
The involvement of NP in either physiological or pathophysiological skin conditions is discussed, and a few questions, which still need to be addressed, are raised, and future directions this field of research should take are outlined.