Seatbelts in CAR therapy: How Safe Are CARS?

@inproceedings{Minagawa2015SeatbeltsIC,
  title={Seatbelts in CAR therapy: How Safe Are CARS?},
  author={Kentaro Minagawa and Xiaoou Zhou and Shin Mineishi and Antonio Di Stasi and Mark Murphy},
  booktitle={Pharmaceuticals},
  year={2015}
}
T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to prevent or abate serious adverse events are required. Pharmacologic therapies; suicide genes; or novel strategies to limit the cytotoxic effect only to malignant cells are under active… CONTINUE READING
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