Seasonal changes in the suprachiasmatic nucleus of man

@article{Hofman1992SeasonalCI,
  title={Seasonal changes in the suprachiasmatic nucleus of man},
  author={Michel A. Hofman and Dick F. Swaab},
  journal={Neuroscience Letters},
  year={1992},
  volume={139},
  pages={257-260}
}
The mammalian suprachiasmatic nucleus (SCN) is considered to be the principal component of the biological clock, generating a wide variety of physiological and behavioral circadian rhythms. In addition to its implication in circadian rhythms, the SCN is also involved in the expression of some seasonal cycles. In the present study we show that the volume of the human SCN and the number of vasopressin-immunoreactive neurons contained within it fluctuate significantly over the year, with values… Expand
Diurnal and Seasonal Rhythms of Neuronal Activity in the Suprachiasmatic Nucleus of Humans
TLDR
Investigation of the brains of 30 young human subjects found that the daily light-dark cycle as well as seasonal variations in photoperiod would affect the vasopressin cell population of the human SCN. Expand
The suprachiasmatic nuclei as a seasonal clock
TLDR
In mammals, the suprachiasmatic nucleus (SCN) contains a central clock that synchronizes daily rhythms in physiology and behavior, and the human SCN has seasonally rhythmic neurotransmitter levels and morphology. Expand
Annual variations in the vasopressin neuron population of the human suprachiasmatic nucleus
TLDR
The findings indicate that photoperiod may be considered a potential environmental factor controlling the activity of the vasopressin system of the human suprachiasmatic nucleus. Expand
Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging
TLDR
It is shown that the number of VP-immunoreactive neurons in the human SCN exhibits a marked diurnal oscillation in young, but not in elderly, people. Expand
Influence of aging on the seasonal rhythm of the vasopressin-expressing neurons in the human suprachiasmatic nucleus
TLDR
It is shown that the number of VP-immunoreactive neurons in the human SCN exhibits a marked annual oscillation in young but not in elderly people, and that the SCN of elderly people showed a disrupted annual cycle with a reduced amplitude. Expand
The human suprachiasmatic nucleus (SCN) in a periodic environment
TLDR
The human suprachiasmatic nucleus (SCN) is a small structure situated on top of the optic chiasm that shows up clearly following staining of its peptidergic neurotransmitters, e. Expand
Suprachiasmatic nucleus in a patient with multiple system atrophy with abnormal circadian rhythm of arginine-vasopressin secretion into plasma
TLDR
The possibility that SCN is involved in MSA and the neurodegeneration in the SCN results in altered circadian rhythm of AVP secretion and nocturnal polyuria is raised. Expand
Functional neuroanatomy and neuropathology of the human hypothalamus
The human hypothalamus is involved in a wide range of functions in the developing, adult and aging subject and is responsible for a large number of symptoms of neuroendocrine, neurological andExpand
Biological rhythms in the human life cycle and their relationship to functional changes in the suprachiasmatic nucleus.
TLDR
The sex differences in theSCN, the doubling of the number of vasopressin neurons in the SCN of homosexual men, and a variety of animal experimental observations indicate that the SCn is involved in sexual behavior and reproduction. Expand
Development of the human hypothalamus
  • D. Swaab
  • Biology, Medicine
  • Neurochemical Research
  • 2005
TLDR
It can be concluded that the various hypothalamic nuclei are involved in a great number of functions and show clear and differential changes in development with respect to sexual differentiation, birth and a number of diseases. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 24 REFERENCES
The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia
TLDR
In both sexes a decrease in SCN volume and cell number was observed in senescence (80-100 years) and the latter change was especially pronounced in patients with senile dementia of the Alzheimer type (SDAT), which suggests the presence of a structural defect in the SCN which underlies the general disturbance of biological rhythms insenescence and SDAT. Expand
Effects of melatonin on vertebrate circadian systems
  • V. Cassone
  • Medicine, Biology
  • Trends in Neurosciences
  • 1990
TLDR
Research indicates that the circadian rhythms of many species of reptiles, birds and mammals, including humans, are synchronized by the administration of exogenous melatonin, and points to the possibility that melatonin or melatonin analogues may be therapeutically useful for the control of circadian clock dysfunctions such as jet lag, shift-work syndrome and sleep disorders. Expand
Morphometric analysis of the suprachiasmatic and paraventricular nuclei in the human brain: sex differences and age-dependent changes.
TLDR
A comparison of the volumetric measurements of the human SCN and PVN with those of the rat showed that the humanSCN is reduced in size relative to other hypothalamic nuclei, mainly caused by cell loss rather than by a reduction in cell size. Expand
Seasonal variation in vasopressin innervation in the brain of the European hamster (Cricetus cricetus)
Using immunocytochemistry, vasopressin innervation was determined in the brain of the European hamster (Cricetus cricetus) during different seasons. It was found that the spring period coincides withExpand
Circadian neural rhythms in mammals.
  • F. Turek
  • Biology, Medicine
  • Annual review of physiology
  • 1985
TLDR
There is no conclusive evidence that circadian rhythms can be generated over a prolonged period of time in the absence of the SCN in mammals maintained under constant environmental conditions, and recent studies in humans suggest that disorders within the circadian system itself may be involved in the etiology of at least some forms of mental illness. Expand
The human hypothalamus: comparative morphometry and photoperiodic influences.
TLDR
A comparative morphometric analysis of the hypothalamus among mammals revealed that the volume of this part of the brain is highly correlated with brain size, irrespective of the ecological strategy or evolutionary history of the species considered, and a marked seasonal variation in the morphology of the human SCN. Expand
An enlarged suprachiasmatic nucleus in homosexual men
Morphometric analysis of the human hypothalamus revealed that the volume of the suprachiasmatic nucleus (SCN) in homosexual men is 1.7 times as large as that of a reference group of male subjects andExpand
Putative melatonin receptors in a human biological clock.
TLDR
The results suggest that putative melatonin receptors are located in a human biological clock, and specifically found in the suprachiasmatic nuclei of hypothalami from adults and fetuses. Expand
Seasonal changes in vasopressin in the brain of the garden dormouse (Eliomys quercinus L.)
The distribution of vasopressin in the brain of the garden dormouse (Eliomys quercinus L.) was examined by immunocytochemistry at different times of the year. In spring‐summer, sexual dimorphism inExpand
...
1
2
3
...