Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasites.

@article{Ord2007SeasonalCO,
  title={Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasites.},
  author={Rosalynn Ord and Ne{\^a}l Alexander and Sam Dunyo and Rachel Hallett and Musa Jawara and Geoffrey A. T. Targett and Christopher J. Drakeley and Colin J. Sutherland},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={196 11},
  pages={1613-9}
}
BACKGROUND Observations in natural Plasmodium falciparum populations after removal of failing drugs suggest that there is a fitness cost of drug resistance. METHODS To examine the effect of transient removal of drug pressure, we analyzed seasonal changes in the prevalence of chloroquine (CQ)-resistant parasite genotypes in The Gambia. Parasite isolates from 441 children presenting with uncomplicated falciparum malaria over 5 seasons (1998-2002) were linked to weekly rainfall data. RESULTS… CONTINUE READING

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