Searching new signals for production traits through gene-based association analysis in three Italian cattle breeds.

@article{Capomaccio2015SearchingNS,
  title={Searching new signals for production traits through gene-based association analysis in three Italian cattle breeds.},
  author={Stefano Capomaccio and Marco Milanesi and L Bomba and Katia Cappelli and Ezequiel L. Nicolazzi and John L. Williams and Paolo Ajmone-Marsan and Bruno Stefanon},
  journal={Animal genetics},
  year={2015},
  volume={46 4},
  pages={
          361-70
        }
}
Genome-wide association studies (GWAS) have been widely applied to disentangle the genetic basis of complex traits. In cattle breeds, classical GWAS approaches with medium-density marker panels are far from conclusive, especially for complex traits. This is due to the intrinsic limitations of GWAS and the assumptions that are made to step from the association signals to the functional variations. Here, we applied a gene-based strategy to prioritize genotype-phenotype associations found for milk… CONTINUE READING
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