Searching for the polycystic ovary syndrome genes.

  title={Searching for the polycystic ovary syndrome genes.},
  author={Margrit Urbanek and Richard S Legro and Deborah Anne Driscoll and Jerome F Strauss and Andrea Dunaif and R. S. Spielman},
  journal={Journal of pediatric endocrinology & metabolism : JPEM},
  volume={13 Suppl 5},
PCOS is a common disorder of unknown etiology. Studies of first-degree relatives of women diagnosed with PCOS suggest familial clustering of the disease. A prospective study of first-degree female relatives of women with PCOS conducted by NCPIR found that 46% of ascertainable sisters of women with PCOS were hyperandrogenemic. NCPIR has conducted linkage and association studies using affected sibling-pair analysis and the transmission/disequilibrium test to explore candidate PCOS genes. These… CONTINUE READING