Searching for replication origins in mammalian DNA.

  title={Searching for replication origins in mammalian DNA.},
  author={A. Falaschi and Mauro Giacca and Lorena Zentilin and Paolo Norio and Silvia Diviacco and Daniela Dimitrova and S. Srinivas Kumar and R. Tuteja and Giuseppe Biamonti and Giovanni Perini},
  volume={135 1-2},
The attempts at identifying precise replication origins (ori) in mammalian DNA have been pursued mainly through physico-chemical and biochemical approaches, in view of the essential failure of the search for autonomously replicating sequences in cultured cells. These approaches involve the mapping of short stretches of nascent DNA, the identification of the… CONTINUE READING