Searching for hypothetical proteins: theory and practice based upon original data and literature.

@article{Lubec2005SearchingFH,
  title={Searching for hypothetical proteins: theory and practice based upon original data and literature.},
  author={Gert Lubec and Leila Afjehi-Sadat and Jae-Won Yang and Julius Paul Pradeep John},
  journal={Progress in neurobiology},
  year={2005},
  volume={77 1-2},
  pages={90-127}
}
A large part of mammalian proteomes is represented by hypothetical proteins (HP), i.e. proteins predicted from nucleic acid sequences only and protein sequences with unknown function. Databases are far from being complete and errors are expected. The legion of HP is awaiting experiments to show their existence at the protein level and subsequent bioinformatic handling in order to assign proteins a tentative function is mandatory. Two-dimensional gel-electrophoresis with subsequent mass… CONTINUE READING
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