Searching for genetic determinants in the new millennium

@article{Risch2000SearchingFG,
  title={Searching for genetic determinants in the new millennium},
  author={Neil Risch},
  journal={Nature},
  year={2000},
  volume={405},
  pages={847-856}
}
  • N. Risch
  • Published 15 June 2000
  • Biology
  • Nature
Human genetics is now at a critical juncture. The molecular methods used successfully to identify the genes underlying rare mendelian syndromes are failing to find the numerous genes causing more common, familial, non-mendelian diseases. With the human genome sequence nearing completion, new opportunities are being presented for unravelling the complex genetic basis of non-mendelian disorders based on large-scale genome-wide studies. Considerable debate has arisen regarding the best approach to… 
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