Searching for genes underlying normal variation in human adiposity

  title={Searching for genes underlying normal variation in human adiposity},
  author={Anthony Gean Comuzzie and Jeff T. Williams and Lisa J Martin and John Blangero},
  journal={Journal of Molecular Medicine},
A primary challenge in biomedical research today is the elucidation of the underlying genetic architecture of complex conditions such as obesity. In contrast to simple Mendelian disorders that result from a mutation in a single gene, complex phenotypes are the product of the action (as well as interaction) of multiple genes and environmental factors. The genetic configuration of these genes can range from effectively polygenic (i.e., many genes each with a relatively small contribution) to… CONTINUE READING