Searching for a structural endophenotype in psychosis using computational morphometry

  title={Searching for a structural endophenotype in psychosis using computational morphometry},
  author={Machteld Marcelis and John Suckling and Peter Woodruff and Paul Hofman and Jim van Os},
  journal={Psychiatry Research: Neuroimaging},
Structural cerebral abnormalities are frequently observed in schizophrenia. These abnormalities may indicate vulnerability for the disorder, as evidenced by reports of familial clustering of measures identified through region-of-interest analyses using manual outlining procedures. We used computational morphometry to detect structural differences within the entire brain to further examine possible structural endophenotypes. Magnetic resonance imaging scans were obtained in 31 psychotic patients… CONTINUE READING


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