Searching for a function for nuclear actin.

  title={Searching for a function for nuclear actin.},
  author={Oliver J Rando and Kun Zhao and Gerald R Crabtree},
  journal={Trends in cell biology},
  volume={10 3},
The abundant cytoskeletal protein actin has numerous cytoplasmic roles. Although there are many reports of the presence of actin in the nucleus, in general they have been discounted as artifactual. However, recent work has begun to provide evidence for important roles for actin in nuclear processes ranging from chromatin remodelling to splicing. In addition, several regulators of actin polymerization are localized to the nucleus or translocate to the nucleus in a regulated manner, suggesting… CONTINUE READING

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