Searching for Type 2 Diabetes Genes in the Post-genome Era

@article{Permutt2000SearchingFT,
  title={Searching for Type 2 Diabetes Genes in the Post-genome Era},
  author={M. Alan Permutt and Andrew T Hattersley},
  journal={Trends in Endocrinology & Metabolism},
  year={2000},
  volume={11},
  pages={383-393}
}
The discovery of genes encoding maturity onset diabetes of the young (MODY) type 2 diabetes mellitus (T2DM) represents a milestone in the study of the genetics of complex diseases. The genes were revealed, in large part, through positional cloning and linkage analysis in families. The genes are relatively rare and have strong genotype-phenotype correlations. Based on the results of several genome scans for genes encoding T2DM in various racial-ethnic groups, it appears that, as in other complex… CONTINUE READING

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