Searching databases of conserved sequence regions by aligning protein multiple-alignments.

@article{Pietrokovski1996SearchingDO,
  title={Searching databases of conserved sequence regions by aligning protein multiple-alignments.},
  author={Shmuel Pietrokovski},
  journal={Nucleic acids research},
  year={1996},
  volume={24 19},
  pages={3836-45}
}
A general searching method for comparing multiple sequence alignments was developed to detect sequence relationships between conserved protein regions. Multiple alignments are treated as sequences of amino acid distributions and aligned by comparing pairs of such distributions. Four different comparison measures were tested and the Pearson correlation coefficient chosen. The method is sensitive, detecting weak sequence relationships between protein families. Relationships are detected beyond… CONTINUE READING
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