Search for the possible role of ‘immunotherapy’ in operable bronchial non-small cell carcinoma (stage I and II): A phase I study with Corynebacterium parvum intrapleurally

@article{Hilgard2004SearchFT,
  title={Search for the possible role of ‘immunotherapy’ in operable bronchial non-small cell carcinoma (stage I and II): A phase I study with Corynebacterium parvum intrapleurally},
  author={Philipp Hilgard and J. Vogt-Moykopf and Bogomir A. Hrabar and Roar Nissen-Meyer and V. O. Bj and Katja Karrer},
  journal={Cancer Immunology, Immunotherapy},
  year={2004},
  volume={4},
  pages={69-75}
}
The possibility of giving C. parvum intrapleurally (i.p.) was investigated. C. parvum was given post-operatively either i.p. only or i.p. and intravenously (i.v.) simultaneously. The dose varied from 0.1–10 mg i.p. All patients had been operated for a bronchial carcinoma. Results: (1) Subjective complaints of either dyspnoea, thoracic pain, chills or nausea occured in 31 of 63 patients. No clear dose relation was found. A feeling of discomfort and fever could occur for another 3–4 days after… CONTINUE READING