Search for the missing lncs: gene regulatory networks in neural crest development and long non‐coding RNA biomarkers of Hirschsprung's disease

@article{Rogers2016SearchFT,
  title={Search for the missing lncs: gene regulatory networks in neural crest development and long non‐coding RNA biomarkers of Hirschsprung's disease},
  author={John M Rogers},
  journal={Neurogastroenterology \& Motility},
  year={2016},
  volume={28}
}
  • J. M. Rogers
  • Published 1 February 2016
  • Biology
  • Neurogastroenterology & Motility
Hirschsprung's disease (HSCR), a birth defect characterized by variable aganglionosis of the gut, affects about 1 in 5000 births and is a consequence of abnormal development of neural crest cells, from which enteric ganglia derive. In the companion article in this issue (Shen et al., Neurogasterenterol Motil 28: 266–73), the authors search for long non‐coding RNAs (lncRNAs) differentially expressed in bowel tissues of infants with HSCR. Microarray analysis of over 37 000 lncRNAs and 34 000… 

LncRNA DRAIC regulates cell proliferation and migration by affecting the miR-34a-5p/ITGA6 signal axis in Hirschsprung’s disease

Rescue experiments have confirmed that DRAIC regulates cell proliferation and migration by affecting the miR-34a-5p/ITGA6 signal axis in HSCR.

Aberrant expression of LINC00346 regulates cell migration and proliferation via competitively binding to miRNA-148a-3p/Dnmt1 in Hirschsprung’s disease

LINC00346 was downregulated in HSCR colon tissues and acted as a ceRNA to regulate the expression of Dnmt1 in vitro and these findings indicate that LINC00 346 could affect the occurrence of HSCr by participating in the development of enteric neural crest cells.

Association between miR-492 rs2289030 G>C and susceptibility to Hirschsprung disease in southern Chinese children

The results suggest that the miR-492 rs2289030 G>C polymorphism is not associated with susceptibility to HSCR in southern Chinese children, and these results need to be further confirmed by investigating a more diverse ethnic population of patients with H SCR.

Upregulation of MiR-369-3p suppresses cell migration and proliferation by targeting SOX4 in Hirschsprung's disease.

Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment

This study transcriptionally identifies molecular pathways and candidate genes that drive specification, differentiation and the neural circuitry of specific neural progenitors, the phox2b expressing ENS cell lineage, during normal enteric nervous system development.

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