Search for the missing lncs: gene regulatory networks in neural crest development and long non‐coding RNA biomarkers of Hirschsprung's disease

  title={Search for the missing lncs: gene regulatory networks in neural crest development and long non‐coding RNA biomarkers of Hirschsprung's disease},
  author={John M Rogers},
  journal={Neurogastroenterology \& Motility},
  • J. M. Rogers
  • Published 1 February 2016
  • Biology
  • Neurogastroenterology & Motility
Hirschsprung's disease (HSCR), a birth defect characterized by variable aganglionosis of the gut, affects about 1 in 5000 births and is a consequence of abnormal development of neural crest cells, from which enteric ganglia derive. In the companion article in this issue (Shen et al., Neurogasterenterol Motil 28: 266–73), the authors search for long non‐coding RNAs (lncRNAs) differentially expressed in bowel tissues of infants with HSCR. Microarray analysis of over 37 000 lncRNAs and 34 000… 

LncRNA DRAIC regulates cell proliferation and migration by affecting the miR-34a-5p/ITGA6 signal axis in Hirschsprung’s disease

Rescue experiments have confirmed that DRAIC regulates cell proliferation and migration by affecting the miR-34a-5p/ITGA6 signal axis in HSCR.

Aberrant expression of LINC00346 regulates cell migration and proliferation via competitively binding to miRNA-148a-3p/Dnmt1 in Hirschsprung’s disease

LINC00346 was downregulated in HSCR colon tissues and acted as a ceRNA to regulate the expression of Dnmt1 in vitro and these findings indicate that LINC00 346 could affect the occurrence of HSCr by participating in the development of enteric neural crest cells.

Association between miR-492 rs2289030 G>C and susceptibility to Hirschsprung disease in southern Chinese children

The results suggest that the miR-492 rs2289030 G>C polymorphism is not associated with susceptibility to HSCR in southern Chinese children, and these results need to be further confirmed by investigating a more diverse ethnic population of patients with H SCR.

Upregulation of MiR-369-3p suppresses cell migration and proliferation by targeting SOX4 in Hirschsprung's disease.

Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment

This study transcriptionally identifies molecular pathways and candidate genes that drive specification, differentiation and the neural circuitry of specific neural progenitors, the phox2b expressing ENS cell lineage, during normal enteric nervous system development.

Epigenetics of muscle disorders



SLIT 2 / ROBO 1-miR-2181-RET / PLAG 1 : a new disease pathway involved in Hirschsprung ' s disease

Altered miR-2181 regulation of SLIT2, RET and PLAG1 might be involved in the pathogenesis of HSCR.

The developmental etiology and pathogenesis of Hirschsprung disease.

Transcriptome analysis reveals novel players in the cranial neural crest gene regulatory network.

The results suggest that ETS1 and SOX9 may act as pan-neural crest regulators of the migratory CNC and identify new links in the gene regulatory network responsible for development of this critical cell population.

Establishing neural crest identity: a gene regulatory recipe

The current status of the neural crest gene regulatory network is reviewed, emphasizing the connections between transcription factors, signalling molecules and epigenetic modifiers.

Nidogen‐1 is a common target of microRNAs MiR‐192/215 in the pathogenesis of Hirschsprung's disease

The miR‐192/miR‐215/NID1 signaling pathway may play an important role in the pathogenesis of HSCR and this cascade is proposed for the proposed mechanism.

MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans

The aim of this review paper is to summarize the existent knowledge on microRNAs related to female fertility and cancer: from primordial germ cells and ovarian function, germinal stem cells, oocytes, and embryos to embryonic stem cells.

MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung’s Disease

Aberrant expression of miR-195 may involved in the pathogenesis of HSCR by down-regulated the level of DIEXF, which induced the impairment of cell migration and proliferation.

Building a brain in the gut: development of the enteric nervous system

This review focuses on the molecular and genetic factors regulating ENS development from NCC, the clinical genetics of HSCR and its associated syndromes, and recent advances aimed at improving the understanding and treatment of enteric neuropathies.