Search for the Most ‘primitive’ Membranes and Their Reinforcers: A Review of the Polyprenyl Phosphates Theory

@inproceedings{Nakatani2014SearchFT,
  title={Search for the Most ‘primitive’ Membranes and Their Reinforcers: A Review of the Polyprenyl Phosphates Theory},
  author={Yoichi Nakatani and Nigel Ribeiro and St{\'e}phane Streiff and Mari Gotoh and Gianluca Pozzi and Laurent D{\'e}saubry and Alain Milon},
  booktitle={Origins of Life and Evolution of Biospheres},
  year={2014}
}
Terpenoids have an essential function in present-day cellular membranes, either as membrane reinforcers in Eucarya and Bacteria or as principal membrane constituents in Archaea. We have shown that some terpenoids, such as cholesterol and α, ω-dipolar carotenoids reinforce lipid membranes by measuring the water permeability of unilamellar vesicles. It was possible to arrange the known membrane terpenoids in a ‘phylogenetic’ sequence, and a retrograde analysis led us to conceive that single-chain… CONTINUE READING