Search for potential autism treatments turns to 'trust hormone'

@article{Opar2008SearchFP,
  title={Search for potential autism treatments turns to 'trust hormone'},
  author={Alisa Opar},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={353-353}
}
  • Alisa Opar
  • Published 1 April 2008
  • Medicine
  • Nature Medicine
For all of the attention that autism has received, the condition still lacks pharmacological treatments. Faced with this frustrating reality, some researchers have begun exploring whether oxytocin, the so-called ‘trust hormone’, could ease symptoms of the disorder, such as repetitive behaviors and difficulties with social interactions. Autism spectrum disorders affect an estimated one in every 150 children in the US alone, according to government statistics. So far, the US Food and Drug… Expand
The Male Prevalence in Autism Spectrum Disorders: Hypotheses on its Neurobiological Basis
The strong male prevalence of autism spectrum disorders represents a challenge to any neurobiological theory of autism. Current genetics does not offer clues to this phenomenon. The authors argueExpand
Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high‐functioning level
TLDR
The results implicate that genetic variation in the OXTR gene might be relevant in the etiology of autism on high‐functioning level. Expand
Intranasal administration of oxytocin: Behavioral and clinical effects, a review
TLDR
It is concluded that IN-OT administration may be a promising approach to influence human communication but that the existing lack of information about the neural and physiological mechanisms involved is a serious problem for the proper understanding and interpretation of the observed effects. Expand
REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
TLDR
This review addresses the issues of drug design and specificity and focuses on recent findings on oxytocin and its heterotrimeric G protein‐coupled receptor OTR to highlight the role of Oxytocin in behavior and affectivity. Expand
The orgasmic history of oxytocin: Love, lust, and labor
TLDR
This small nine amino acid peptide is now believed to be involved in a wide variety of physiological and pathological functions such as sexual activity, penile erection, ejaculation, pregnancy, uterine contraction, milk ejection, maternal behavior, social bonding, stress and probably many more, which makes oxytocin and its receptor potential candidates as targets for drug therapy. Expand
The Oxytocin of Love in the Context of Medical Science
‘What else is the help of medicine than love?’ Pure love constitutes not only the de facto, but also, the de jure criterion of the intention not to depart from the legal discipline which is theExpand
Lost connections: Oxytocin and the neural, physiological, and behavioral consequences of disrupted relationships.
  • Tobias T. Pohl, L. Young, O. Bosch
  • Medicine, Psychology
  • International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2019
TLDR
The translational value of animal models for investigating the oxytocinergic mechanisms that underlie the detrimental effects of developmental parental neglect and pair bond disruption are demonstrated, encouraging future translationally relevant studies on this topic that is so central to the authors' daily lives. Expand
Oxytocin receptor ligands: a survey of the patent literature
TLDR
These ligands are expected to show therapeutic utility for a vast range of applications, e.g., increasing lactation, improving in vitro inseminations, and inducing cardiomyogenesis; and also acting against preterm labor, breast cancer, an over-reactive immune system, osteoporosis, and autism-related disorders. Expand
Title: The Role of Oxytocin in Maternal-Fetal Bonding & Social Interaction
Oxytocin is a small peptide usually associated with its effects in the reproductive system such as induction of labor and lactation. However, recent evidence has indicated that oxytocin plays anExpand
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
TLDR
It is suggested that 'CSF-oxytocin' contributes considerably to the non-synaptic communication processes involved in hypothalamic-, brainstem- and olfactory brain areas and behavioral states and that the flowing CSF is used as a 'broadcasting system' to send coordinated messages to a wide variety of nearby and distant brain areas. Expand
...
1
2
...

References

SHOWING 1-6 OF 6 REFERENCES
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
TLDR
Patients with autism spectrum disorders showed a significant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion, and may be partially ameliorated by synthetic oxytocIn infusion. Expand
Oxytocin Increases Retention of Social Cognition in Autism
TLDR
The results of this study suggest that oxytocin might facilitate social information processing in those with autism and provide preliminary support for the use of Oxytocin in the treatment of autism. Expand
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
TLDR
Data suggest an involvement of OXTR in the susceptibility to autism, and replication is important. Expand
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
TLDR
Support is provided for association of OXTR with autism in a Caucasian population by overtransmission of the G allele to probands with autistic disorder and the haplotype test of association did not reveal excess transmission from parents to affected offspring. Expand
Plasma oxytocin levels in autistic children
TLDR
The data suggest that OT abnormalities may exist in autism, and that more direct investigation of central nervous system OT function is warranted, after making inferences to central OT functioning from peripheral measurement. Expand
Oxytocin and the molecular basis of monogamy.
TLDR
Screen genomic libraries from prairie and montane voles to determine if species differences in OTR promoters account for the strikingly different patterns of regional expression in brain should ultimately provide insight into a neuroendocrine mechanism for pair bond formation. Expand