Search for new genetic biomarkers in poorly differentiated and anaplastic thyroid carcinomas using next generation sequencing.

@article{Skorov2015SearchFN,
  title={Search for new genetic biomarkers in poorly differentiated and anaplastic thyroid carcinomas using next generation sequencing.},
  author={Vlasta S{\'y}korov{\'a} and S{\'a}rka Dvoř{\'a}kov{\'a} and Josef Vcelak and Eli{\vs}ka V{\'a}clav{\'i}kov{\'a} and Tereza H{\'a}lkov{\'a} and Daniela Kodetov{\'a} and Petr Lastůvka and Jan Betka and Petr Vl{\vc}ek and Martin Řeboun and Rami Katra and Bela Bendlova},
  journal={Anticancer research},
  year={2015},
  volume={35 4},
  pages={2029-36}
}
BACKGROUND Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are very rare tumors with extremely aggressive behavior. Their comprehensive genetic background is still unclear. Some of the main genetic changes of differentiated thyroid carcinomas, such as mutations in BRAF and RAS genes, as well as changes in CTNNB1, PIK3CA, TP53, AXIN1, PTEN or APC genes leading to the dedifferentiation of the tumors, are described. MATERIALS AND METHODS DNAs from fresh… CONTINUE READING
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