Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation.

@article{Okada1995SearchFN,
  title={Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation.},
  author={Yoshio Okada and Nanako Miyauchi and Kei Suzuki and Tomoshige Kobayashi and Chihiro Tsutsui and Kimine Mayuzumi and Sansei Nishibe and Toru Okuyama},
  journal={Chemical & pharmaceutical bulletin},
  year={1995},
  volume={43 8},
  pages={1385-7}
}
An EtOAc extract of Artemisiae Capillari Spica inhibited both bovine lens aldose reductase (bovine-LAR) and rabbit platelet aggregation. Two simple coumarins, scoparone (1) and scopoletin (2), and three flavonoids, capillarisin (21), cirsimaritin (22) and rhamnocitrin (23), were isolated from this extract. Scoparone (1) and scopoletin (2) exhibit a potent inhibitory effect on rabbit platelet aggregation induced by four types of agent, ADP, PAF, sodium arachidonate and/or collagen. Capillarisin… CONTINUE READING
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