Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.

@article{Danilenko2008SearchFI,
  title={Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.},
  author={V. Danilenko and A. Y. Simonov and S. A. Lakatosh and M. Kubbutat and F. Totzke and C. Schaechtele and S. Elizarov and O. Bekker and S. S. Printsevskaya and Yuryi N Luzikov and M. I. Reznikova and A. Shtil and M. Preobrazhenskaya},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 24},
  pages={
          7731-6
        }
}
  • V. Danilenko, A. Y. Simonov, +10 authors M. Preobrazhenskaya
  • Published 2008
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • Aminomethylation of 9b,10-dihydro-1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino-[1,7-a]indole-1,3(2H)-diones or 1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino[1,7-a]indole-1,3(2H)-diones resulted in dialkylaminomethyl derivatives. Alkylation of the nitrogen atom of maleimide moiety of polyannelated diazepines with 1,3-dibromopropane and subsequent reaction with thiourea or its N-alkyl derivatives gave isothiourea-carrying compounds. The compounds containing isothiourea moiety were… CONTINUE READING

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