Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives.

Abstract

In an effort to design new hybrid compounds with dual properties, i.e. binding affinity at histamine H(3) receptors and inhibitory potency at the catabolic enzyme histamine N(tau)-methyltransferase (HMT), a novel series of 1-substituted piperidine derivatives was synthesized. This alicyclic heterocycle is structurally linked via aminoalkyl spacers of… (More)

Topics

Cite this paper

@article{Grassmann2004SearchFH, title={Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives.}, author={Sven Grassmann and Joachim Apelt and Xavier Ligneau and Heinz H. Pertz and J M Arrang and C. Robin Ganellin and J S Schwartz and Walter Schunack and Holger Stark}, journal={Archiv der Pharmazie}, year={2004}, volume={337 10}, pages={533-45} }